The most direct difference between metronidazole and demenidazole is that metronidazole is used by human and demenidazole is used by animal.
Metronidazole has broad-spectrum anti anaerobe and antigenic effect. It is mainly used to treat or prevent systemic or local infection caused by anaerobe, such as abdominal cavity, digestive tract and female reproductive system. And trichomonal vaginitis.
Demenidazole can also resist trichomonad and spirochete, and is mainly used for histotrichomoniasis and haemodysentery of piglets caused by spirochete.
Tinidazole is the second generation of nitramide antibacterials, which lasts longer than that of metronidazole, and its activity is 2 to 4 times stronger.
Ornidazole is used to treat various diseases caused by anaerobes, trichomonas in urogenital tract of men and women, amebiasis of intestine and liver, and to prevent and treat anaerobes infection after operation.
Ornidazole is the third generation of nitroimidazoles. Its minimum inhibitory concentration and minimum bactericidal concentration are lower than metronidazole and Tinidazole, and its antibacterial advantage is obvious. At the same time, its plasma elimination half-life is 14.4 hours, longer than metronidazole and Tinidazole, so the efficacy lasts longer