Doxycycline is a traditional tetracycline antibiotic. It mainly combines with 30S ribosomal subunits by penetrating the cell membrane, interfering with the bacterial tRNA/mRNA interaction, and finally inhibiting bacterial protein synthesis to play an antibacterial role.
Recent studies have shown that Doxycycline also has many other non-antibiotic biological effects.
It can partially protect MTECI against MMC-induced apoptosis through the MAPK pathway and promote the proliferation of mouse thymic epithelial cell lines; at the same time, it can also promote the secretion of IL-6 and GM-CSF by MTECI through the NF-KB and MAPK pathways
Thymus epithelial cells can promote the development and differentiation of thymus cells. In clinical treatment of doxycycline, the damage to the cellular immune system caused by the disease is promoted by repair and reconstruction. Therefore, in addition to broad-spectrum antibacterial and anti-mycoplasma effects, doxycycline also has a non-antibiotic immunity-enhancing effect.
Does doxycycline treat all diseases, and when is the best effect? The following is a brief analysis:
1. Briefly summarized as "two bacteria, four bodies, one insect spirit"
2. Two bacteria refer to bacteria and actinomycetes. Most of the bacterial diseases, doxycycline are effective, so they are often used to treat respiratory diseases.
3. Tetrabody refers to mycoplasma (asthma, cough will be combined with doxycycline); chlamydia; spirochete; Rickett's organism.
4. A worm refers to blood protozoa, such as amoeba, erythrocyte body also belongs to blood protozoosis.