Application of Sulfa Drugs In Breeding

- Feb 05, 2021-


Sulfa drugs are antibacterial drugs, which have the advantages of wide antibacterial coverage, stable efficacy and low price,and can be stored for a long time.Sulfa drugs are used frequently in the breeding process!For example, poultry coccidiosis, white crown disease, and rhinitis diseases; swine Toxoplasma, streptococcus, eperythrocytes and other common diseases are also often used in sulfa drugs for treatment, and the effect is also very good.Here are some tips, let's learn.


1.Choose different types of sulfa drugs according to the nature of the disease

Systemic infectious diseases: For sepsis, drugs that are easily absorbed by the intestine, such as sulfadiazine.

                                                                  CAS 68-35-9


Intestinal infections: such as enteritis, diarrhea, drugs that are not easily absorbed by the intestine, such as sulfamidine.

                                                                 CAS 57-60-0


Parasitic infections: such as coccidia and leukocytosis infection,such as sulfamethazine.

                                                             CAS 57-68-1/ 80-32-0

2.Determine the time and dose of the medication based on the nature of the sulfa drugs

The dosage of sulfa drugs is divided into assault dosage and maintenance dosage.


For all surprise attacks, the dosage was doubled within a safe range on the first or first day, and then changed to the normal dosage.


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3.Cooperative application of sulfa drugs

Combined with sodium bicarbonate: Sulfonamide drugs are easy to crystallize in acidic environment. If sulfa drugs are used alone, sulfa crystals will appear when excreted by the kidneys and block the ureter. So use it with  sodium bicarbonate to prevent crystals from appearing. In addition, sulfa drugs should be banned when renal function decline or systemic acidosis occurs.


Combined use with synergist: sulfa drugs and synergist are used together (5:1), the antibacterial effect is 10times stronger than that of simple use.


Combined with VK and VB: when sulfa drugs are used, they affect the intestinal absorption of VK and VB. Therefore, when using sulfa drugs, VK/VB should be added to the feed.


When using sulfa drugs, accurate dosage and uniform mixing are required. The course of treatment is 3 to 5 days, not more than 7 days. Because long-term large-scale use can cause poisoning.


4.Tips for sulfa to improve its effect

1)Sulfonamides have poor solubility and poor water solubility. It is recommended to choose              sodium sulfa drugs in the clinical process, such as sulfapentamethoxine sodium. Comes the point: the sodium salt form of sulfonamides is very water soluble, and it is recommended to use.


2)What is the correct ratio of sulfa drugs to tmp?

     5:1 --The ratio of other antibiotics to TMP is generally 4:1, but sulfonamides are 5:1


3)Berberine + Sulfa = Synergism

     Use sulfa drugs to treat enteritis, and add some berberine, there will be a pleasant effect.


4)Can aminophylline be used with sulfa drugs?

     In fact, we can adjust the amount of aminophylline to match. The concentration should be       adjusted to 1g aminophylline to 40 kg of water, which is half the normal dosage.


5)Sulfonamide drugs inhibit bacteria, so in general, prevention is the priority, and medication       cannot be continued during treatment.


5.Precautions for the use of sulfa drugs

Sulfonamides can not be used 3 days after the vaccine, because sulfonamides can inhibit antigen activity and reduce the immune effect.


When sulfa drugs are used externally, the wound pus and necrotic tissue should be completely removed, because these substances contain a large amount of p-hydrobenzoic acid, which affects the efficacy of the drug.


Incompatibility:

Liquid sulfa drugs are not easy to combine with acid drugs, such as vitamin B, vitamin C, penicillin, tetracycline, etc., otherwise sulfa precipitation will occur. The efficacy of sulfa drugs and procaine used together will weaken or even fail. 




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